Production Chemist - Mid Shift- San Diego
About this role
Production Chemist - Mid Shift
Location: San Diego, CA | Employment Type: Full-Time
PolyPeptide is seeking a Production Chemist (I, II, and III) to support the manufacture of high-quality Active Pharmaceutical Ingredients (APIs) in a cGMP-regulated environment. These roles are critical to our mission of delivering safe, effective, and on-time pharmaceutical products to patients worldwide.
Whether you are early in your career or an experienced chemist ready to lead, we offer a clear growth path, hands-on manufacturing experience, and the opportunity to work with advanced peptide synthesis and purification technologies.
What You’ll Do (All Levels)
As a Production Chemist, you will be responsible for executing and supporting peptide manufacturing operations across upstream synthesis and downstream purification , while maintaining strict compliance with cGMP, safety, and quality standards.
Core Responsibilities
• Execute batch production records (BPRs) accurately and in compliance with SOPs and GxP requirements • Operate and monitor chemical processes including reactors, drying systems, purification HPLCs, and lyophilization • Perform in-process controls (IPCs) and interpret analytical results (e.g., HPLC, ninhydrin tests) • Ensure proper material handling, inventory management, and ERP documentation following ALCOA+ principles • Maintain high standards of safety, cleanliness, PPE usage, and 5S practices • Communicate effectively with cross-functional teams including QA, QC, Maintenance, Engineering, and Supply Chain
Level-Based Scope & Growth
Production Chemist I
• Entry-level to early-career role with hands-on manufacturing responsibility • Works under general supervision following established procedures • Focused on execution, learning cGMP operations, and building technical expertise • Ideal for candidates new to peptide manufacturing or regulated production environments
Production Chemist II
• Experienced individual contributor with increasing autonomy • Troubleshoots process deviations, supports investigations, and assists with CAPAs and quality documentation • Trains and mentors Chemist I team members • Participates in process improvements, tech transfers, and scale-up activities
Production Chemist III